Browsing by Author "Ilic M."

Now showing 1 - 17 of 17

Bevacizumab combined with chemotherapy improves survival for patients with metastatic colorectal cancer: Evidence from meta analysis
(2016) Ilic I.; Jankovic, Slobodan; Ilic M.
© 2016 Ilic et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Background: Colorectal cancer is one of the leading causes of cancer deaths in both sexes in the world. Improvement of existing therapy modalities and implementing new ones in order to improve survival of patients with colorectal cancer represents a great challenge for medicine. The aim of this paper was to assess the impact that adding bevacizumab to chemotherapy has on survival in patients with metastatic colorectal cancer, compared to the use of chemotherapy alone. Methods: Hazard ratios (HRs) with their 95% confidence intervals (CI) were determined from the studies and pooled. Two-sided p values were reported and considered to indicate statistical significance if less than 0.05. Results: A total of 12 studies that meet the inclusion criteria were identified in the literature search, 3 phase II studies and 9 phase III studies. Based on the random effects meta-analysis, a statistically significant improvement was identified for both overall survival (HR = 0.84; 95% CI: 0.74-0.94; p = 0.003) and progression free survival (HR = 0.64; 95% CI: 0.55-0.73; p<0.00001) in patients with metastatic colorectal cancer when bevacizumab was added to chemotherapy, compared to chemotherapy treatment alone. Conclusion: The findings of this meta analysis confirm the benefit of adding bevacizumab to chemotherapy in terms of survival and progression free survival, but the magnitude of this effect is not consistent throughout the included studies. This suggests the need for further research of interaction of bevacizumab with chemotherapeutic agents as well as recognition of patients' characteristics important for the treatment selection criteria.
Biological activities of sanguisorba minor l. extracts ñ in vitro and in vivo evaluations
(2021) Ćirović N.; Barjaktarevic A.; Ninkovic M.; Bauer, Rudolf; NIKLES S.; Branković, Snežana; Markovic M.; Jovanovic V.; Ilic M.; Milovanovic, Olivera; Kojicic K.; Cupara S.
© 2020 Polish Pharmaceutical Society. All rights reserved. The literature data about Sanguisorba minor L. subsp. muricata Briq. (fam. Rosaceae) are limited. It has been used in folk medicine for its diuretic and digestive properties, or in the treatment of fever and diarrhea. The aim of the study was to evaluate the antioxidant, antimicrobial and anti-inflammatory potential of S. minor subsp. muricata root extracts (in vitro and in vivo). Methanol, ethanol and chloroform extracts were characterized by total phenolic and flavonoid content. Antioxidant activity was estimated by five different assays in vitro, and in vivo in the animal model of sepsis. Antimicrobial activity was tested against Gram-positive bacteria, Gram-negative bacteria and one fungus by micro-well dilution assay. Cyclooxygenase-1 inhibition assessment of S. minor ethanol extract was performed in the presence of Indomethacin. Ethanol and methanol extracts did not differ significantly in the content of phenols and flavonoids, as well as in achieved antioxidant activity. Both of these extracts were superior to the chloroform extract. Ethanol and methanol extracts showed similar antimicrobial activity. Chloroform extract exhibited strong activity against all examined strains of bacteria, but moderate against Candida albicans. Ethanol extract induced 76% inhibition of Cyclooxygenase-1 in vitro. The same extract decreased the level of the oxidative stress parameters in an animal model of sepsis. All extracts exhibited considerable antimicrobial and antioxidant activities, while ethanol extract showed anti-inflammatory potential. Based on the effects achieved on oxidative stress parameters in sepsis, S. minor could be considered as a herbal adjuvant antioxidant therapy in systemic infectious treatment.
Breast cancer and p16: Role in proliferation, malignant transformation and progression
(2021) Jovanovic D.; Mitrović V.; Milosavljevic, Milos; Ilic M.; Stankovic, Vesna; Vuletic, Milena; Dimitrijevic Stojanovic, Milica; Milošev D.; Azanjac G.; Nedeljkovic V.; Radovanovic D.
The definition of new molecular biomarkers could provide a more reliable approach in predicting the prognosis of invasive breast cancers (IBC). The aim of this study is to analyze the expression of p16 protein in IBC, as well as its participation in malignant transformation. The study included 147 patients diagnosed with IBC. The presence of non-invasive lesions (NIL) was noted in each IBC and surrounding tissue. p16 expression was determined by reading the percentage of nuclear and/or cytoplasmic expression in epithelial cells of IBC and NIL, but also in stromal fibroblasts. Results showed that expression of p16 increases with the progression of cytological changes in the epithelium; it is significantly higher in IBC compared to NIL (p < 0.0005). Cytoplasmic p16 expression is more prevalent in IBC (76.6%), as opposed to nuclear staining, which is characteristic of most NIL (21.1%). There is a difference in p16 expression between different molecular subtypes of IBC (p = 0.025). In the group of p16 positive tumors, pronounced mononuclear infiltrates (p = 0.047) and increased expression of p16 in stromal fibroblasts (p = 0.044) were noted. In conclusion, p16 protein plays an important role in proliferation, malignant transformation, as well as in progression from NIL to IBC.
Can Didactic Continuing Education Improve Clinical Decision Making and Reduce Cost of Quality? Evidence From a Case Study
(2015) Vukovic M.; Gvozdenović B.; Rankovic M.; McCormick B.; Vuković D.; Gvozdenović B.; Kastratovic D.; Marković, Dušan; Ilic M.; Jakovljevic, Mihajlo
© 2015 The Alliance for Continuing Education in the Health Professions, the Society for Academic Continuing Medical Education, and the Council on Continuing Medical Education, Association for Hospital Medical Education. Introduction: Administration of human serum albumin (HSA) solutions for the resuscitation of critically ill patients remains controversial. The objective of this study was to assess the effect of continuing medical education (CME) on health care professionals' clinical decision making with regard to HSA administration and the costs of quality (COQ). A quasi-experimental study of time series association of CME intervention with COQ and use of HSA solution was conducted at the Surgery Department of the Hospital Valjevo, Serbia. The CME contained evidence-based criteria for HSA solution administration in surgical patients. The preintervention period was defined as January 2009 to May 2011. CME was provided in June 2011, with the postintervention period June 2011 to May 2012. Methods: Total mortality rate, the rate of nonsurgical mortality, the rate of surgical mortality, the rate of sepsis patient mortality, index of irrational use of HSA solutions, and number of hospital days per hospitalized patient were collected for each month as quality indicators. Statistical analysis was performed by multivariate autoregressive integrated moving average (MARIMA) modeling. The specification of the COQ was performed according to a traditional COQ model. Results: The CME intervention resulted in an average monthly reduction of the hospital days per hospitalized patient, the rate of sepsis patient mortality, index of irrational use of HSA solutions, and COQ for $593,890.77 per year. Discussion: Didactic CME presenting evidence-based criteria for HSA administration was associated with improvements in clinical decisions and COQ. In addition, this study demonstrates that models combining MARIMA and traditional COQ models can be useful in the evaluation of CME interventions aimed at reducing COQ.
DFT study of free radical scavenging activity of erodiol
(2013) Marković, Zoran; Crossed D Signorović J.; Dekic, Milan; Radulović M.; Markovic, Svetlana; Ilic M.
Antioxidant activity of erodiol was examined at the M05-2X/6-311+G(d,p) level of theory in the gas and aqueous phases. The structure and energy of radicals and anions of the most stable erodiol rotamer were analyzed. To estimate antioxidant potential of erodiol, different molecular properties were examined: bond dissociation enthalpy, proton affinity together with electron transfer energy, and ionization potential followed by proton dissociation enthalpy. It was found that hydrogen atom transfer is the prevailing mechanism of erodiol behavior in gas; whereas single electron transfer followed by proton transfer and sequential proton loss electron transfer mechanisms represent the thermodynamically preferred reaction paths in water. © 2013 Institute of Chemistry, Slovak Academy of Sciences.
Ethics of neuroscience and neuroscience ethics: To meet the future
(2015) Pantović M.; Pantovic M.; Pantović M.; Ilic M.
© 2015, Serbian Medical Society. All Rights Reserved. The foundations of medical ethics, laid by Hippocrates, grew from ancient philosophy. During the course of time and through development of science, ethics has been transformed from normative to the applied. One of the newest branches, neuroethics, has opened two new fields of research: ethics of neurosciences and neurosciences of ethics. Due to new discoveries, these fields raise numerous questions concerning neurodiagnostics, stimulation of nerve structures, “cosmetic” psychopharmacology, problems of conscience, free will, etc. In empathy, as the basis of ethics, the latest findings point out the crucial role of mirror neurons. Groups of these neurons, scattered throughout the central nervous system, form a special matrix whose activity can be indirectly registered by positron emission tomography (PET) and functional magnetic resonance imaging (fMRI). Today there is a growing knowledge of motor, affective and cognitive aspects of empathy and of the brain structure involved in empathy, giving it biological basis, which sets the path for further research.
Improving the accuracy of SVM algorithm in classification problems with PCA method
(2018) Novakovic J.; Alempije, Veljovic; Ilic M.; Veljović, Vladimir
© Springer International Publishing AG 2018. This paper investigates the use of SVM algorithm with PCA method in classification, which is one of the most common task of machine learning. Classification is the problem of identifying to which of a set of categories a new observation belongs, on the basis of a training set of data containing observations (or instances) whose category membership is known. SVM algorithm can produce accurate and robust classification results on a sound theoretical basis, even when input data are non-monotone and non-linearly separable. So they can help to evaluate more relevant information in a convenient way. PCA method reduces the dimensionality and the maximum number of new variables that can be obtained is equal to the original, with new variables are not correlated with each other. Experimental studies have shown that it is possible to improve the accuracy of SVM classification algorithm using PCA method.
Long-term results of laparoscopic gastric sleeve resection due to morbid obesity and metabolic syndrome
(2018) Ilic M.; Putnik S.; Raspopovic K.
© 2018, Serbia Medical Society. All rights reserved. Introduction The aim of this paper was to presents long-term results of a laparoscopic gastric sleeve resection in a “super super” obese patient and a follow-up period of eight years. Case outline A patient with body mass index of 70 kg/m2 and Stage 3 obesity according to the King’s Obesity Staging Criteria, with metabolic syndrome and cardiovascular risk of over 20%, and a pronounced severe obstructive sleep apnea, underwent a laparoscopic gastric sleeve resection. After two years, the patient reached body mass index of 28.4 kg/m2 and eight years after the surgery has a body mass index of 34.3 kg/m2, and the percentage of excess body mass index loss of 79.3%. According to the King’s Obesity Staging Criteria, he falls under Stage 0. Conclusion Laparoscopic gastric sleeve resection may be performed as a stand-alone procedure in “super super” obese patients, with excellent long-term results.
Mortality from stomach cancer in Serbia, excluding the Province of Kosovo, in the 1991-2009 period
(2013) Ilic M.; Prodović T.; Milosavljevic Z.; Ljujic, Biljana
Background/Aim: Stomach cancer is the second most common cause of death from all malignant tumors in the world (thirdin men, fifth in women), with a strong decreasing trend in most developed countries. The aim of this descriptive epidemiological study was to analyze mortality of stomach cancer in Serbia, excluding the Province of Kosovo, in the 1991-2009 period. Materials and Methods: In data analysis, we used mortality rates which were standardized directly using those of the world population as a standard. In order to analyze the mortality trend from stomach cancer, linear trend and regression analysis were used. Confidence intervals (CIs) for the average age-adjusted and age-specific mortality rates were assessed with 95% level of probability. Mortality data were derived from the data file of the Statistical Office of the Republic of Serbia. Results: During the 1991-2009 period, a significant downward trend in mortality of stomach cancer was recorded in Serbia (y=9.78 - 0.13x, p=0.000; average annual percent change was - 6.3 (95%CI, -7.8 to - 4.8). During the same period, asignificant decrease in mortality trend was found both in male (y=14.13 - 0.20x; p=0.000; % change was -7.7 (95%CI, -10.9 to -4.5) and female populations (y=6.27 - 0.08x; p=0.000; % change was - 4.4 (95%CI, -5.3 to -3.6). Conclusion: Decreasingtrends in mortality from stomach cancer in Serbia are similar to those in most developed countries.
Myocardial infarction and alcohol consumption: A case-control study
(2018) Ilic M.; Sipetic S.; Ristic, Branko; Ilic I.
© 2018 Ilic et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Background Although epidemiological evidence for the beneficial effect of low alcohol consumption on myocardial infarction is strong, the impact of heavy drinking episodes is less clear. Objectives The aim of this study was to investigate a possible association between the risk for acute myocardial infarction occurrence and alcohol consumption. Methods Our hospital-based case-control study comprised 374 participants (187 newly diagnosed patients with myocardial infarction and 187 controls, individually matched by gender, age, and place of residence). This study was performed in Kragujevac (a city in Serbia) during 2010. Logistic regression analysis was used to determine odds ratio (OR) with 95% confidence intervals (95% CI). Results The history of alcohol consumption in patients with acute myocardial infarction and their controls did not differ significantly: the percentage of those that were consuming alcohol was slightly higher in cases (54.5%) than in controls (50.3%). The habit of binge drinking during the previous 12 months was significantly more common in cases (25.1%) than in controls (12.8%): adjusted OR = 2.2 (95%CI = 1.2–4.2, p = 0.017), p for trend = 0.015. Analysis of binge drinking by age, gender and place of residence revealed that the increase in risk for acute myocardial infarction was associated with older age (adjusted OR = 5.1, 95%CI = 1.7–15.1, p for trend = 0.010), male gender (adjusted OR = 2.3, 95%CI = 1.1–5.2, p for trend = 0.028) and rural place of residence (adjusted OR = 4.8, 95%CI = 1.3–18.5, p for trend = 0.033). Conclusion Our results suggest that binge drinking is associated with twice the risk for myocardial infarction compared to not drinking. Since consumption of alcohol is very common in the Serbian population, the effect of binge drinking on myocardial infarction should be considered an important public health issue.
Psychological distress among women with abnormal pap smear results in Serbia: Validity and reliability of the Cervical Dysplasia Distress Questionnaire
(2019) Ilic I.; Babic, Goran; Dimitrijevic, Aleksandra; Ilic M.; Grujicic J.
© 2019 Ilic et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Background Receiving report of an abnormal finding from a Pap screening test in women often leads to psychological distress. Objectives The purpose of this study was to assess the reliability and validity of the Cervical Dysplasia Distress Questionnaire (CDDQ) among women in Serbia. Methods In 2017, we conducted a cross-sectional study involving 154 consecutive women attending cervical cancer screening who had received abnormal Pap smear results. Results Reliability assessment showed good internal consistency for all CDDQ subscales (Tension and discomfort: Cronbach’s α = 0.844; Embarrassment: α = 0.864; Sexual and reproductive consequences: α = 0.867; and Health consequences: α = 0.913). The test-retest reliability showed that the correlation coefficients (between 0.805 and 0.983) were significant at the 0.01 level for all of the Serbian CDDQ subscales. Principal Axis Factoring with Direct Oblimin rotation indicated four main components that explain 55.0% of variance. Conclusion The Serbian version of the CDDQ scale is a valid and reliable instrument for the assessment of psychological distress among women with abnormal Pap smear results.
The association between obesity and visit-to-visit variability in systolic blood pressure: A prospective study
(2017) Stojanović E.; Ilic M.; Ilić K.; Tasic N.; Ilic B.; Petrovic, Dejan; Dragisic D.; djukic, aleksandar; Jovanovic M.
© 2017, University of Kragujevac, Faculty of Science. All rights reserved. With the prevalence of obesity and all accompanying health risks, both prevention and health education, as well as identifying predictors for the development of obesity-related diseases are primary. The pathophysiological relationship between obesity and visit-to-visit variability in systolic blood pressure (SBPV) has not been completely resolved. To investigate the association between obesity and SBPV in hypertensive patients. The prospective study comprised three visits was performed at the hypertension outpatient clinic during the follow up period of 22-months between March 2014 and January 2016. This study included 300 randomly selected hypertensive patients (average 67.76±9.84 years), who were divided in groups of obese/non-obese examinees. SBPV was defined as the standard deviation (SD) from three values of SBP. The values of SBP and SBP-SD were significantly higher in the group of obese hypertensive patients than in the group of non-obese patients (126.67±8.22 vs 120.45±7.79 mmHg, 11.00±5.64 vs 7.34±3.96; p<0.01). The highest SBPV was recorded in the 4th quartile in obese patients (43.13±7.50 mmHg). There was statistically stronger correlation between SBPV and BMI/Waist cirumferences (WC) (ρο=0.425/ ρο=0.356, p<0.01). During 22-months follow up there was a significant decrease of SBPV for 8.2 mmHg, BP for 31/8 mmHg, BMI for 3.8 kg/m2, WC for 10 cm and body weight for 8.24 kg. During 22-months follow-up, reduction of body weight was associated with reduction of blood pressure variability in hypertensive patients. Persistently decrease both body weight and long term visit-to-visit variability may explain lower cardiovascular risk in obese-related disease.
The effects of N-acetylcysteine on cisplatin-induced changes of cardiodynamic parameters within coronary autoregulation range in isolated rat hearts
(2016) Rosic, Gvozden; Selakovic, Dragica; Joksimovic, Jovana; Srejovic I.; Zivkovic V.; Tatalović, Nikola; Orescanin Dusic, Zorana; Mitrović V.; Ilic M.; Jakovljevic V.
© 2015 Elsevier Ireland Ltd. The aim of this study was to evaluate the effects of chronic NAC administration along with cisplatin on cisplatin-induced cardiotoxicity by means of coronary flow (CF), cardiodynamic parameters, oxidative stress markers and morphological changes in isolated rat heart. Isolated hearts of Wistar albino rats (divided into four groups: control, cisplatin, NAC and cisplatin+NAC group) were perfused according to Langendorff technique at constant coronary perfusion pressure starting at 50 and gradually increased to 65, 80, 95 and 110cm H2O to evaluate cardiodynamic parameters within autoregulation range. Samples of coronary venous effluent (CVE) were collected for determination of CF and biochemical assays, and heart tissue samples for biochemical assays and histopathological examination. Cisplatin treatment decreased CF and heart rate, and increased left ventricular systolic pressure and maximum left ventricular pressure development rate. Cisplatin increased H2O2 and TBARS, but decreased NO2- levels in CVE. In tissue samples, cisplatin reduced pathological alterations in myocardium and coronary vessels, with no changes in the amount of total glutathione, as well as in activity of glutathione peroxidase and glutathione reductase. NAC coadministration, by reducing oxidative damage, attenuated cisplatin-induced changes of cardiodynamic and oxidative stress parameters, as well as morphological changes in myocardium and coronary vasculature.
The Expression of IL-1β Correlates with the Expression of Galectin-3 in the Tissue at the Maternal–Fetal Interface during the Term and Preterm Labor
(2022) Jovic, Nikola; Milovanovic, Marija; Jovic J.; Ilic M.; Rakić, Dejana; Milenković V.; Stojanovic, Bojana; Milovanovic, Jelena; Arsenijević, Aleksandar; Arsenijevic, Nebojsa; Varjacic, Mirjana
The inflammatory processes that occur at the maternal–fetal interface are considered one of the factors that are responsible for preterm birth. The pro-inflammatory roles of the Gal-3-induced activation of NLRP3 inflammasome and the consecutive production of IL-1β have been described in several acute and chronic inflammatory diseases, but the role of this inflammatory axis in parturition has not been studied. The aim of this study was to analyze the protein expression of Gal-3, NLRP3, and IL-1β in the decidua, villi, and fetal membranes, and to analyze their mutual correlation and correlation with the clinical parameters of inflammation in preterm birth (PTB) and term birth (TB). The study included 40 women that underwent a preterm birth (gestational age of 25.0–36.6) and histological chorioamnionitis (PTB) and control subjects, 22 women that underwent a term birth (gestational age of 37.0–41.6) without histological chorioamnionitis (TB). An analysis of the tissue sections that were stained with anti- Gal-3, -NLRP3, and -IL-1β antibodies was assessed by three independent investigators. The expression levels of Gal-3 and IL-1β were significantly higher (p < 0.001) in the decidua, villi, and fetal membranes in the PTB group when they compared to those of the TB group, while there was no difference in the expression of NLRP3. A further analysis revealed that there was no correlation between the protein expression of NLRP3 and the expression of Gal-3 and IL-1β, but there was a correlation between the expression of Gal-3 and IL-1β in decidua (R = 0.401; p = 0.008), villi (R = 0.301; p = 0.042) and the fetal membranes (R = 0.428; p = 0.002) in both of the groups, PTB and TB. In addition, the expression of Gal-3 and IL-1β in decidua and the fetal membranes was in correlation with the parameters of inflammation in the maternal and fetal blood (C-reactive protein, leukocyte number, and fibrinogen). The strong correlation between the expression of Gal-3 and IL-1β in the placental and fetal tissues during labor indicates that Gal-3 may participate in the regulation of the inflammatory processes in the placenta, leading to increased production of IL-1β, a cytokine that plays the main role in both term and preterm birth.
The influence of the expression of steroid receptors on angiogenesis, proliferation and apoptosis in myomas of pre-and postmenopausal women
(2019) Kljakic D.; Raicevic, Sasa; Milosavljevic, Milos; Ilic M.; Zivanovic, Aleksandar; Radonjić D.; Mitrovic M.
© 2019, Serbia Medical Society. All rights reserved. Introduction/Objective The aim of this study was to determine the effects of the estrogen and progesterone receptor status on angiogenesis, proliferation, and apoptosis of myoma cells in premenopausal (PreM) and postmenopausal (PostM) women. Methods This was a cross section; clinical-experimental, retrospective, non-interventional study in the field of the study of fundamental pathogenesis mechanisms of disease using pathohistological materials from the existing archive. The research included 76 patients diagnosed with uterine leiomyomas, operatively treated in the Clinic for Gynecology and Obstetrics, Clinical Centre Kragujevac, Serbia. According to the menstrual status, we formed two experimental subgroups. The first group was PreM women (n = 35; 46.2 ± 5.02 years old), and the second group was PostM women (n = 41; 60.25 ± 5.41 years old). Hema-toxylin-eosin staining for myoma and myometrium was conducted, as well as immunohistochemistry for ERα, ERβ, PRа, vascular endothelial growth factor, endoglin, Ki67, and caspase-3. Results Progesterone receptor was overexpressed in myoma and myometrium of PreM compared to myoma and myometrium of PostM women. Expression of caspase-3 was a statistically significant increase in PostM women compared to PreM group. ERα and ERβ were not changed among groups neither in myoma nor in myometrium samples. Conclusion According to our data, PRа had higher influence on apoptosis and cell growth than estrogen receptors. Since PRа was increased in PreM in both myoma and myometrium, probably this expression led further to lower expression of apoptotic marker in PreM women.
Trends in cerebrovascular diseases mortality in Serbia, 1997-2016: A nationwide descriptive study
(2019) Ilic, Milena; Ilic M.; Sipetic Grujicic S.
© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. Objectives Over the last decades, mortality from cerebrovascular diseases (CVDs) has decreased in many countries. The aim of this study was to assess the trends of CVDs mortality in Serbia. Methods Descriptive epidemiological study. Age-standardised rates (ASRs) for CVDs mortality were assessed by joinpoint regression analysis to identify significant changes in trends and estimate annual per cent changes with 95% CI. The age-period-cohort analysis has been used to describe variations in mortality. Results Over this 20-year period, there were 312 847 deaths from CVDs, with the overall average annual ASR of 148.4 per 100 000. The trend of ASRs from CVDs mortality in males in Serbia showed a significant joinpoint: rates insignificantly decreased from 1997 to 2005 by '0.8% per year (95% CI '1.7% to 0.2%) and thereafter rapidly decreased by '5.0% per year (95% CI '5.6% to '4.5%). A joinpoint for females was found in 2006: the mortality trend was first significantly decreasing by '1.0% per year (95% CI '1.9% to '0.0%) and then sharply falling down by '6.0% per year (95% CI '6.8% to '5.3%). Results of age-period-cohort analysis indicated that the relative risk for CVDs mortality showed statistically significant (p<0.05) cohort and period effects, as well as the net drift and local drifts in Serbian population. The trends in mortality for all subtypes of CVDs were similar in both sexes: trends significantly decreased for most subtypes, with the exception of a significant increase for cerebral infarction. Conclusions After a decade of increase, CVDs mortality rates are declining in last decade in Serbia. However, mortality rates from CVDs remain exceedingly high in Serbia. Differences in mortality trends of the stroke subtypes should be taken into account in the creation of both prevention and treatment guidelines.
Vaccine-associated paralytic poliomyelitis: A case report
(2014) Ilic M.; Obradovic, Slobodan