(University of Kragujevac, Faculty of Medical Sciences, 2021) Sekulic, Sofija; Mijailovic, Zeljko; Petrovic, Dejan; Lukic, Ruzica; Jovanovic, Marina; Jovanovic, Ivan
Chronic Hepatitis C virus (HCV) infection is defined as per-sistence of HCV RNA in the blood for more than six months. HCV is a major cause of chronic liver disease and cirrhosis. It’s serious public health problem, affects about 71 million people worldwide. HCV doesn’t destroy hepatocytes directly. It activates the host's innate and acquired immune system and causes liver injury indi-rectly. Behind hepatic, HCV can cause extra-hepatic manifesta-tions. One of them is renal disease which can lead to end-stage renal disease, ESRD. The prevalence of HCV infection in patients on hemodialysis is high, ranging from 5% to 60%. HCV infection is a significant cause of morbidity and mortality in patients with ESRD on hemodialysis. In this review, we discuss HCV infection and chronic renal disease as comorbidities, their severity and out-come.