Role of Galectin-3 in Tumour Metastasis

dc.contributor.author	Radosavljevic, Gordana
dc.contributor.author	Jovanovic I.
dc.contributor.author	Knezevic M.
dc.contributor.author	Zdravkovic, Nemanja
dc.contributor.author	Pavlovic S.
dc.contributor.author	Lukic, Miodrag
dc.contributor.author	Arsenijevic, Nebojsa
dc.date.accessioned	2021-04-20T15:02:32Z
dc.date.available	2021-04-20T15:02:32Z
dc.date.issued	2010
dc.description.abstract	We used metastatic variant of B16 melanoma (B16F1) to study lung colonization galectin-3-deficient (gal-3-/-) C57BL/6 mice. In vivo study showed that compared with gal-3+/+ mice, gal-3-/-mice exhibited resistance to lung colonization of B16F1 melanoma cells (p < 0.03). In vitro assays showed higher number of attached malignant cells in the tissue section derived from gal-3+/+ mice (p < 0.001) and tumor specific cytotoxicity of lymphoid cells of tumour inoculated gal-3-/- suggesting that galectin-3 is considered as therapeutic target. © 2010 Allerton Press, Inc.
dc.identifier.doi	10.3103/S0027131410030107
dc.identifier.issn	0027-1314
dc.identifier.scopus	2-s2.0-77956608737
dc.identifier.uri	https://scidar.kg.ac.rs/handle/123456789/10163
dc.rights	restrictedAccess
dc.source	Moscow University Chemistry Bulletin
dc.title	Role of Galectin-3 in Tumour Metastasis
dc.type	article

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