BY-NC-NDAntonijević, MarkoSimijonović, DušicaKesić, AnaAvdović, EdinaMarkovic, Zoran2021-05-142021-05-1420219788687611801https://scidar.kg.ac.rs/handle/123456789/13197Coumarins are a widespread group of compounds. They have a wide range of physiological effects, from antifungal, through anticoagulant to anticancer, and therefore they have found wide application in the treatment of various diseases. In this paper, the ability of 4-hydroxy-3-methoxy-N'-((E)-1-(2,4-dioxo-2H-chromen- 3(4H)-ylidene)ethyl)benzohydrazide to inactivate ROS was investigated. The analysis of the obtained results showed that the SET-PT (Single Electron Transfer Followed By Proton Transfer) mechanism is non-operative. On the other hand, the thermodynamic parameters describing the HAT *Hydrogen Atom Transfer) and the first step of the SPLET (Sequential Proton Loss-Electron Transfer) mechanism indicate that both mechanisms will be operative. The antiradical capacity of the test compound with the radicals decreases in the following order: •OH> •OCH3> •OC(CH3)3> •OOH> •OOCH3> •OOCH2CH3.sropenAccesshttps://creativecommons.org/licenses/by-nc-nd/4.0/Antiradical activityDFTThermodynamic approachTermodinamički pristupconferenceObject10.46793/SBT26.423A