Čolović N.Perunicić M.Jurisic, VladimirColovic, Mirjana2021-04-202021-04-2020101357-0560https://scidar.kg.ac.rs/handle/123456789/10157Skin involvement in hairy cell leukemia (HCL) at presentation is a relatively rare manifestation of the disease. A 60-year-old male patient in whom cutaneous lesions were the initial manifestation of hairy cell leukemia together with leukocytosis, monocytopenia, massive splenomegaly, and leukemic maculopapulous infiltration of the almost whole skin is described. The present case is the forth mentioned in the literature with specify of leukocytosis in peripheral blood, consisting mostly of hairy cells. The patient was treated with two courses of 2-chlorodeoxiadenosine (2-CdA, Cladribine) and splenectomy and after this cutaneous lesion disappeared and general condition is improved. © 2009 Humana Press Inc.restrictedAccessreview10.1007/s12032-009-9246-42-s2.0-77956902273