Salinger, SonjaDimitrijevic, ZoricaStanojevic D.Momcilovic M.Kostic, TomislavKoracévić G.Subotic B.Dzudovic B.Stefanovic B.Matijasevic J.Miric M.Markovic Nikolic, NatasaNikolic M.Miloradović V.Kos L.Kovacevic Preradovic T.Srdanovic I.Stanojevic, JelenaObradović R.2021-04-202021-04-2020200167-5273https://scidar.kg.ac.rs/handle/123456789/12915© 2019 Elsevier B.V. Background: Acute pulmonary embolism (PE), due to hemodynamic disturbances, may lead to multi-organ damage, including acute renal dysfunction. The aim of our study was to investigate the predictive role of renal dysfunction at admission regarding the short-term mortality and bleeding risk in hospitalized PE patients. Methods: The retrospective cohort study included 1330 consecutive patients with PE. The glomerular filtration rate (GFR) was calculated using the serum creatinine value and Cocroft-Gault formula, at hospital admission. Primary outcomes were all-cause mortality and PE-related mortality in the 30 days following admission, as well as major bleeding events. Results: Based on the estimated GFR, patients were divided into three groups: the first with GFR < 30 mL/min, the second with GFR 30–60 mL/min, and the third group with GFR > 60 mL/min. A multivariable analysis showed that GFR at admission was strongly associated with all-cause death, as well as with death due to PE. Patients in the first and second group had a significantly higher risk of 30-day all-cause mortality (HR 7.109, 95% CI 4.243–11.911, p < 0.001; HR 2.554, 95% CI 1.598–4.081, p < 0.001). Fatal bleeding was recorded in 1.6%, 0.5% and 0.8% of patients in the first, second and in the third group (p < 0.05). There were no significant differences regarding major bleeding rates among the groups. Conclusion: Renal dysfunction at admission in patients with acute pulmonary embolism is strongly associated with overall PE mortality.restrictedAccessarticle10.1016/j.ijcard.2019.12.0252-s2.0-85076826149