Synthesis, cytotoxic activity, and thermal studies of novel N-[(1,3-diphenylpyrazol-4-yl)methyl] α-amino acids

Joksović, MilanBogdanovic, GordanaKojić, VesnaMészáros Szécsényi, KatalinLeovac V.Jakimov, DimitarTrifunović, SnežanaMarković, VioletaJoksović, Ljubinka2021-04-202021-04-2020100022-152Xhttps://scidar.kg.ac.rs/handle/123456789/10201(Chemical Equation Presented) New N-[(1,3-diphenylpyrazol-4-yl)methyl]a- amino acids (1a-i) have been synthesized and tested in vitro for their antiproliferative activity against human myelogenous leukemia K562, colon adenocarcinoma HT-29, cervix carcinoma HeLa, and normal fetal lung fibroblasts, MRC-5. Compounds derived from both phenylalanine enantiomer precursors appeared to be the most active against myelogenous leukemia K562 cell lines with a high cytotoxic potential. © 2010 HeteroCorporation.restrictedAccessSynthesis, cytotoxic activity, and thermal studies of novel N-[(1,3-diphenylpyrazol-4-yl)methyl] α-amino acidsarticle10.1002/jhet.4002-s2.0-77954598700