Stereospecific ligands and their complexes. Part XV. Synthesis, characterization and cytotoxicity of novel platinum(IV) complexes with some esters of ethylenediamine-N, N' N′ -di-S, S-(2,2′ -dibenzyl)acetic acid. Crystal structure of O, O′ -dipropyl-ethylenediamine -N, N′ -di-S, S-(2,2′ -dibenzyl)acetate dihydrochloride

Dimitrijević D.Glocrossed D Signović V.Radic G.García-Granda, SantiagoMenéndez-Taboada L.Milovanovic, MarijaVolarevic, VladislavArsenijevic, NebojsaBogdanovic, Goran A.Trifunović, Srećko2021-04-202021-04-2020130020-1693https://scidar.kg.ac.rs/handle/123456789/10438The synthesis of ethylenediamine-N,N′'-di-S,S-(2,2′'-dibenzyl) acetic acid (H2-S,S-eddba) and its ethyl-, propyl-, butyl- esters (R2-S,S-eddba) are reported here. The esters were used for synthesis of the corresponding platinum(IV) complexes, [PtCl4(R 2-S,S-eddba)]. The compounds were characterized by elemental analysis, infrared, 1H and 13C NMR spectroscopy. The structure of propyl ester of H2-S,S-eddba was confirmed by single-crystal X-ray analysis. All [PtCl4(R2-S,S-eddba)] complexes displayed significantly higher in vitro cytotoxicity in comparison to cisplatin. © 2013 Published by Elsevier B.V.restrictedAccessStereospecific ligands and their complexes. Part XV. Synthesis, characterization and cytotoxicity of novel platinum(IV) complexes with some esters of ethylenediamine-N, N' N′ -di-S, S-(2,2′ -dibenzyl)acetic acid. Crystal structure of O, O′ -dipropyl-ethylenediamine -N, N′ -di-S, S-(2,2′ -dibenzyl)acetate dihydrochloridearticle10.1016/j.ica.2013.03.0392-s2.0-84877087811