Institute for Information Technologies, Kragujevac

Permanent URI for this collectionhttps://dspace.unic.kg.ac.rs/handle/123456789/13385

Institute for Information Technologies covers several different fields of scientific studies through the exchange of information technology which covers the Faculty of Science, technical-technological studies, medical studies, biotechnical and social studies. By covering different fields of studies, the Institution creates a collaboration between the research groups of every field mentioned above, and by doing so it provides a better quality in research. As a result of its activities, the Institution provides the possibility of multidisciplinary research and collaboration of different researches. By following all of the latest research trends in modern science, and with the constant growth of computer science along with informational-communicative technology, the main idea of the Institution will be to develop this type of network.

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Scientific research of the Institution is focused on fundamental, applied research and basic focused research. It covers research programs in the fields of technological development, programs for knowledge transfer, and the stimulative use of scientific research results.

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In vitro and in silico lipoxygenase inhibition studies and antimicrobial activity of pyrazolyl-phthalazine-diones
(University of Kragujevac, Faculty of Science, 2021) Milovanović, Vesna; Petrović, Zorica; Petrović, Vladimir; Simijonović, Dušica; Mladenović, Milan; Tomaševic, Nevena; Čomić, Ljiljana; Radojevic, Ivana
The series of pyrazolyl-phthalazine-dione derivatives (PPDs) was subjected to evaluation of their in vitro lipoxygenase (LOX) inhibition and antimicrobial activities. Results obtained for LOX inhibition activities of PPDs showed that all compounds exhibit good to excellent activity, whereby compounds with eudesmic, syringic, vanillic or toluic moiety are the most active. Molecular modelling study was performed to investigate the possible mechanism of action and binding mode of compounds within the LOX active site. Docking results revealed that activity of the examined compounds depends on the functional group ability to create hydrogen bond accepting (HBA) and hydrophobic features (Hy) in the LOX-Ib active site. In addition, all substances were tested for their antibacterial and antifungal activities. The investigated compounds showed better antifungal than antibacterial activity. The highest antifungal activity was on Aspergillus fumigatus ATTC 204305 and Trichoderma viridae ATCC 13233.
Synthesis of series of different imidazolidine-2,4-dione derivatives and evaluation of their antimicrobial potential
(University of Kragujevac, Faculty of Science, 2022) Šmit, Biljana; Radojevic, Ivana; Stanić, Petar; Ašanin, Darko; Vasić, Marijana; Katanić Stanković, Jelena S.
A series of twenty two different imidazolidine-2,4-dione derivatives, divided according to their structure into five groups, including alkyl, alkenyl or aryl 5,5disubstituted hydantoins, spirohydantoins, and fused bicyclic and tricyclic hydantoins, was synthesized and examined for in vitro antimicrobial activity against 15 strains of bacteria and 4 strains of yeast. The antimicrobial activity was evaluated by the determination of the minimal inhibitory concentration (MIC) and the minimal microbicidal concentration (MMC) using the microdilution method. The assayed compounds exerted moderate antibacterial and weak antifungal activity. The antimicrobial activities were influenced by the structure and concentration of the tested compounds as well as the type of test microorganisms. The fused bicyclic hydantoin derivatives obtained by organoselenium induced intramolecular cyclization exhibited the highest inhibitory activity. The examined hydantoin derivatives seem as drug-like candidate for further evaluation of biological activities.

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Browsing Institute for Information Technologies, Kragujevac by Subject "antimicrobial activity"