Institute for Information Technologies, Kragujevac

Permanent URI for this collectionhttps://dspace.unic.kg.ac.rs/handle/123456789/13385

Institute for Information Technologies covers several different fields of scientific studies through the exchange of information technology which covers the Faculty of Science, technical-technological studies, medical studies, biotechnical and social studies. By covering different fields of studies, the Institution creates a collaboration between the research groups of every field mentioned above, and by doing so it provides a better quality in research. As a result of its activities, the Institution provides the possibility of multidisciplinary research and collaboration of different researches. By following all of the latest research trends in modern science, and with the constant growth of computer science along with informational-communicative technology, the main idea of the Institution will be to develop this type of network.

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Scientific research of the Institution is focused on fundamental, applied research and basic focused research. It covers research programs in the fields of technological development, programs for knowledge transfer, and the stimulative use of scientific research results.

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Now showing 1 - 20 of 664

Steel frame versus rack supported warehouse structures
(2017) Vujanac, Rodoljub; Zivkovic, Miroslav; Slavkovic R.; Vulovic, Snezana
Steel frame buildings based on vertical steel columns and horizontal beams or lattice are the most common style for industrial and distribution warehouses. Depending on the use, these typical warehouses are equipped with various types of free standing racks. Construction of self-supporting pallet racking warehouse, as a special form of pre-fabricated building, consists mainly of the racking system elements supporting the roof and walls, and also serves to storage materials. All elements are made of structural thin-walled steel profiles that provide the necessary lightness and low cost of construction. In this paper two systems of warehouse buildings are presented. Two structural designs are analysed and compared in terms of their construction process, technical feasibility with storage capacity, time advantage, economic viability and flexibility of usage.
Academia-industry Collaboration for Augmented Reality Application Development
(2019) Petruse, Radu Emanuil; Alexandru M.; Kayser M.; Maier M.; Cukovic, Sasa
Due to our previous experience in AR development, with this research project we propose to study how Augmented Reality (AR) can be adopted by an industrial partner and which are the major outcomes from which a company may benefit. For this purpose, we partnered with a forward-looking company willing to embrace the idea of implementing new technologies for industrial purposes. In this research we identified that the most significant impact which AR may have for our industrial partner is in providing remote assistance and for product exploitation and marketing purposes. For the latest we developed a customized AR application which is currently available on Apple's App Store. By analysing the app analytics data, we found out that this application is a success in terms of marketing and not only. For the remote assistance AR app, we chose to use a commercial solution that can be adapted to fit our industrial partner's needs. We also tested this application and found out that it greatly improves the communication between remote users thus dismissing the required assistance time.
Numerical Simulation of Sedimentation Process using Mason-Weaver Equation
(2021) Nikolic, Milica; Sustersic, Tijana; Filipovic, Nenad
The paper describes mathematical model and numerical simulation of Mason-Weaver equation using finite difference method, FDM, for simulation of sedimentation process. Different FDM schemes have been developed and tested for several different initial conditions. Possible issues with numerical convergence and conservation of concentration are explained. Performed analysis can be important for any numerical simulation that captures sedimentation process. The results of this research can be further used in modelling epithelial cell behavior and lung-on-a-chip systems.
Semi-Automatic Left Ventricle Model Generation
(2021) Milicevic, Bogdan; Milosevic, Miljan; Simic, Vladimir; Zamaklar-Trifunović D.; Filipovic, Nenad; Kojić M.
Most cardiac diseases and disorders occur in the left ventricle. Numerical methods can give an insight into the mechanical response of the left ventricle under different conditions, before the execution of clinical trials and experiments. Before we use the finite element method to analyze the behavior of the left ventricle, a geometrical model has to be generated. In our work, we generated a left ventricle model from echocardiographic data. We manually extracted contours of the inner and outer surface of the left ventricle and applied our algorithm to generate the 3D model. This semi-automatic model generation enables the usage of patient-specific geometries for finite element analysis of the left ventricle.
Parallelization of lattice Boltzmann software for execution on multi-GPU clusters with application to the simulation of blood flow through human arteries
(2021) Djukic, Tijana; Filipovic, Nenad
It is important to consider the blood flow pattern when planning vascular interventions of atherosclerotic plaques. Large scale computer modeling can be very helpful in this case. The software presented in this paper numerically models blood flow through patient-specific blood vessels. Lattice Boltzmann method was used to simulate blood flow. The principles of GPU (Graphics Processing Unit) programming are applied during implementation and the developed software was parallelized using the CUDA (Compute Unified Device Architecture) and optimized to run on a multi-GPU cluster using the MPI approach. Using the multi-GPU infrastructure, numerical simulations can utilize larger amount of memory resources for the computation, making the level of reality of the models an order of magnitude higher. Execution of the presented software enables fast and reliable case-studies and parametric analyses useful for medical decision-making. The presented software can give medical professionals fast quantitative information about fluid flow in diseased arteries and assist them in selecting the most appropriate treatment.
Analysis of forces in knee joints of top football players and futsal players in different types of jumps
(2021) Radakovic, Radivoje; Janković, Nenad; Dimitrijević J.; Petrović N.; Vulović, Aleksandra; Filipovic, Nenad
In this paper, we will consider the forces in knee joints in football and futsal players during different types of jumps. We will consider two types of jumps: jumps with flywheel and jumps without flywheel. This study has two main aims. The first aim is to compare the knee joint forces in football players and futsal players during different types of jumps. The second aim is to determine the distribution of deformation and stress in menisci of the knee joints in football and futsal players. Professional futsal players performed jumps that were analyzed using a force plate and high-speed video camera system. For this purpose, a 3D model of the human knee joint was developed from medical scans. The 3D model of the human knee joint consisted of femur, fibula, tibia, articular cartilage, ligaments and menisci. Loads and material characteristics were adopted from the literature. The use of finite elements analysis enabled us to gain better understanding of the distribution of deformation and stress in specific parts of the knee joint, with the special focus on the menisci.
A Microfludic Platform as An in Vitro Model for Biomedical Experimentation - A Cell Migration Study
(2021) Milivojević, Nevena; Caballero D.; Carvalho, Mariana; Kokanovic, Mihajlo; Živanović, Marko; Filipovic, Nenad; Reis, Rui L.; Oliveira, Joaquim Miguel
Preclinical experimentation demands for highly reliable and physiologically-relevant systems capable of recapitulating the complex human physiology. Further technological advances are in great need for improving our understanding about critical biological processes involved in tissue development or cancer progression, and for the discovery and screening of novel pharmacological drugs. Traditional in vitro models, albeit widely employed, fail to reproduce the complexity of the native scenario. Similarly, in vivo animal models poorly mimic the human condition and they are ethically questionable. During the last two decades, a new paradigm in preclinical modelling has emerged aiming to solve the limitations of the previous methods. The combination of advanced tissue engineering, cell biology and nanotechnology, has resulted in the development of cutting-edge microfluidics-based models with an unprecedented ability to recreate the native habitat of cells within a microengineered chip. Among the diverse variety of micro- and bio- fabrication techniques, UV-photolithography and soft lithography are considered the gold-standard methods for the fabrication of microfluidic chips to their simplicity, versatility, and rapid prototyping. In this paper, we describe a protocol for the fabrication of a microfluidic chip by UV-photolithography and replica molding, and an example of its use in cell migration assays.
Numerical modelling in assessment of different colorectal cancer cell lines behavior in treatment with cisplatin
(2021) Šeklić, Dragana; Djukic, Tijana; Živanović, Marko; Jovanović, Milena; Filipovic, Nenad
Colorectal cancer is one of the most common types of cancer and metastasis particular problem in anticancer treatment. Therefore, it is crucial to understand key steps in metastasis formation, such as loss of adherent junctions. mathbf{E} -cadherin and beta -catenin are proteins involved in cell-cell junctions in cancer cells. Present study aimed to explain changes in E-cadherin and beta -catenin in two colorectal cancer cell lines after treatment with standard anticancer drug cisplatin, by using numerical modelling. The validity of the mathematical model was tested by experimental measurement of E-cadherin and beta -catenin protein expression by immunofluorescent method. Our results shows that the numerical model of the Wnt pathway completely confirms experimental results for HCT-116 cells, while for SW-480 cells this model should be adjusted.
Analysis of knee joint forces in different types of jumps of top futsal players at the beginning and at the end of the preparation period
(2021) Radakovic, Radivoje; Mijailović, Bratislav; Petrović N.; Vulović, Aleksandra; Filipovic, Nenad; Zdravkovic, Nebojsa
In this study, we will consider the forces in the knee joints of futsal players at the beginning and at the end of the training process focusing on two types of jumps: jumps without swing and jumps with swing. This study has two main objectives. The first objective is to compare the forces in the knee joint at the beginning and at the end of the training process in jumps without a swing and in jumps with a swing. The second objective is to show the distribution of deformations and stresses in the menisci of the knee joint at the beginning and at the end of the training process. Professional futsal players performed jumps that were analyzed using a force plate and high-speed video camera system. For this purpose, a 3D model of the human knee joint was developed from medical scans consisting of femur, fibula, tibia, articular cartilage, ligaments and menisci. Loads and material characteristics were adopted from the literature. Using finite element analysis, we were able to obtain a better insight into the distribution of deformation and stress in particular parts of the knee joint.
Molecular docking study of coumarin-hydroxybenzohydrazide hybrid as an inhibitor of carbonic anhydrases IX and XII
(2021) Antonijević, Marko; Simijonović, Dušica; Milenkovic, Dejan; Marković, Zoran
Carbonic anhydrase isoforms IX and XII are crucial for the regulation of extracellular pH thus facilitating cancer cell proliferation, invasion, and metastasis. Therefore, discovering good inhibitors of CA-IX and CA-XII is of great importance. In this study, the inhibitory activity of previously synthesized coumarin-hydroxybenzohydrazide 3a and its parent molecule 4-hydroxycoumarin, against enzymes CA-IX and CA-XII was investigated. For that purpose, the molecular docking study was performed. The activity of both investigated compounds was calculated for neutral and anionic species. The obtained results indicate that compound 3a expresses good inhibitory activity towards both investigated enzymes, but inhibitory activity is significantly better towards CA-XII than CA-IX.
Computational Modeling of Sarcomere Protein Mutations and Drug Effects on Cardiac Muscle Behavior
(2021) Prodanovic, Momcilo; Stojanović, Boban; Prodanović, Danica; Filipovic, Nenad; Mijailovich S.
Hypertrophic and Dilated Cardiomyopathies are caused by inherited mutations in sarcomeric proteins: Myosin (M), Troponin (Tn), Tropomyosin (Tm) and Myosin Binding Protein-C (MyBP-C). A quantitative understanding of how mutations change protein behaviour, and hence cardiac muscle contraction, and how adaptations to these changes result in disease, could accelerate the design of novel personalized treatments and therapeutics. Newly developed multiscale computational tools, tightly interlaced with multiple experiments, can enhance efforts to correct the problems associated with cardiomyopathies and prevent or more effectively manage the disease. Using these computational tools, we examined the effects of mutations in myosin and troponin on cardiac muscle contractility and overall heart functional behaviour. We also examined the effects of potential therapeutics that modulate protein interactions and cardiac muscle contractility.
Automatic Curvature Analysis for Finely Interpolated Spinal Curves
(2021) Neghina, Mihai; Petruse, Radu Emanuil; Cukovic, Sasa; Schiau C.; Filipovic, Nenad
Assessment of the spinal disorders is a notoriously difficult problem, even in controlled environments where the patients are instructed to stand upright. The method presented here considers the analysis of the mathematical curvature of the scaled and interpolated spinal line, in both the sagittal and frontal planes. Although the number of assumptions for spine normality is kept to a (reasonable) minimum, we demonstrate good detection of sharp or otherwise unnatural local bending in adolescent spinal alignments.
Determination of VEGF and CXCR4 in Tumor and Peritumoral Tissue of Patients with Breast Cancer as a Predictive Factor
(2021) Cvetkovic, Danijela; Cvetković, Aleksandar; Nikodijević, Danijela; jovankic, jovana; Milutinović, Milan; Stojic, Vladislava; Zdravkovic, Natasa; Mltrovic S.
Despite the obvious progress in the field of diagnosis and therapy, further measures are needed to increase the effectiveness of treatment and reduce morbidity and mortality from breast cancer. An immunofluorescence method was used to determine the protein expression of VEGF and CXCR-4 in tumor and peritumoral tissue. Peritumoral tissue is not only a passive factor, but actively participates in the process of tumor growth and development, as well as in the processes of recurrence and metastasis. Markers of neoangiogenesis in tumor and peritumoral tissue such as protein expression of VEGF and CXCR-4 receptors may serve as reliable predictors of disease outcome in breast cancer patients, which may provide useful suggestions in treatment choices.
Inhibitory potency of Valsartan/Sacubitril drug combination: Molecular docking simulations
(2021) Jovanović, Jelena; Marković, Zoran; Kokanovic, Mihajlo; Filipovic, Nenad; Stanojevic Pirkovic, Marijana
Heart failure (HF) is a condition that affects mostly older populations. It can be treated with different medications, and one of them is Entresto. This is a medication which is consisting of two drugs, sacubitril (SAC) and valsartan (VAL). Here, in this study, are performed molecular docking simulations in order to examine the inhibitory potency of SAC and VAL towards neprilysin (NEP) and angiotensin II receptor (AT2), respectively. The achieved thermodynamic parameters shows that SAC and VAL can bind to targeted protein, and inhibit NEP and AT2. The best binding sites are determined. Also, the amino acids responsible for binding are identified.
Toxicity, structural analysis, and molecular docking studies of selected isonicotinohydrazide analogs
(2021) Rakic, Aleksandra; Dimic, Dusan; Dimitrić Marković J.; Milenkovic, Dejan; Marković, Zoran
The isonicotinohydrazide moiety is a common structural motif of the biologically active compounds with pronounced therapeutic effects. Four isonicotinohydrazide analogs were investigated to elucidate the importance of various substituents on the predicted biological activity. The structures of these compounds were optimized at the M06-2X16-311++G(d, p) level of theory based on the crystallographic structures. The intermolecular interactions governing the stability of these compounds were analyzed by the Natural Bond Orbital theory. The molecular docking studies towards Cyclin-Dependent Kinase 2 (CDK2) were performed and the specific interactions of present substituents were described. The absorption, distribution, metabolism, excretion, and toxicity (ADMET) properties of these compounds were predicted by the SWISSADME and Prediction of Toxicity (ProTox-II) webservers. The ecotoxicity study also showed that these compounds might be potentially toxic towards fish, daphnia, and green algae. The similarity in toxicity and reactivity of these compounds is a consequence of the present substituents.
3D reconstruction and computational modeling of solid-fluid interaction in realistic heart model
(2021) Simic, Vladimir; Milosevic, Miljan; Saveljic, Igor; Milicevic, Bogdan; Filipovic, Nenad; Kojić M.
In this report we present basic steps in the 3D reconstruction process of DICOM images and application of our finite element (FE) numerical procedure for loose coupling solid-fluid interaction, to simulate a complete heartbeat cycle for a realistic model of the left heart side. Passive mechanical stresses are calculated using an orthotropic material model based on the experimental investigation of passive material properties of the myocardium, while active stresses are calculated using the Hunter material model. The basic equations for solid mechanics, fluid dynamics, and muscle activation are summarized and model applicability is illustrated on a complex realistic model which includes a left atrium, ventricle, mitral and aortic valves (which serve as fluid domain) coupled with solid wall with realistic fiber directions.
Numerical simulation of fractional flow reserve in atherosclerotic coronary arteries
(2021) Saveljic, Igor; Djukic, Tijana; Nikolic, Dalibor; Djorovic S.; Filipovic, Nenad
Cardiovascular diseases are the leading cause of death in the world with an incidence of about 30% of total mortality. It is a disease of the blood vessels of the heart that most often occurs due to the process of atherosclerosis. The process of atherosclerosis leads to narrowing of the coronary arteries, and thus to a reduced supply of blood or oxygen to the heart muscle. A fractional flow reserve (FFR) indicates the severity of blood flow blockages in the coronary arteries and allows physicians to identify which specific lesion or lesions are responsible for patient ischemia. In this paper, we studied the values of the FFR, using numerical simulations, on the geometries obtained by reconstructing the angiogram images.
Computational model for simulation of left ventricle behaviour during heart beat
(2021) Milosevic, Miljan; Milicevic, Bogdan; Simic, Vladimir; Geroski, Vladimir; Filipovic, Nenad; Kojić M.
The heart is a complex organ which produces mechanical force needed for the blood flow. Electrical signals are transformed into active stresses which contract the heart muscle and pump the blood out from the left ventricle. Therefore, comprehensive numerical procedure has to be established in order to simulate this process and to investigate the effects of different drugs on heart behavior. We here present application of the finite element (FE) computational model for simulation of heart beat cycle of the parametric left ventricle model. We are using Hunter excitation model for active, and direct experimental constitute relations for passive mechanical stresses. Additionally, computational model includes hysteretic and compressible behavior according to the experimental investigations. Applicability of our computational model is demonstrated using parametric left ventricle model which includes inlet mitral and outlet aortic valve cross-sections. With using different boundary conditions and prescribed values, this model has potential to mimic the effects of different drugs on heart beat cycle.
Cost-effectiveness analysis of in silico clinical trials of vascular stents
(2021) Gacic, Marija; Kaplarevic M.; Filipovic, Nenad
The world stent market has an estimated value of €6.4 billion, of which 37% is generated in the US and 10% in the EU. Coronary stents are now the most commonly implanted medical devices, with more than 1 million implanted annually. Coronary stents are currently the most widely used for treating symptomatic coronary disease. In this study, the traditional approach for today's clinical trials with only 10% success rate was described. Within the EU funded project InSilc (www.insilc.eu) was developed the innovative platform for designing, developing and assessing coronary stents. It consists of separate modules and some of them can be used as a standalone tool. Description of each module was given. Cost-effectiveness analysis described the calculation method of the prices of each module as well as platform as a whole, per one stent simulation. The average cost per patient for the execution of a real clinical trial was calculated. The calculated price for in silico trials is below breakeven point in comparison to real clinical trial.
Estimation of Shear Stress Variation in Extracellular Matrix Caused by Duchenne Muscular Dystrophy
(2021) Prodanovic, Momcilo; Prodanović, Danica; Stojanović, Boban; Filipovic, Nenad; Jovicic G.; Mijailovich S.
Continuous degeneration of muscle tissue, inflammatory processes and fibrosis characterized by a loss of muscle mass, formation of micro-scars, adipose tissue in the muscles and eventual muscle punctures are often signs of muscular dystrophies (dystrophinopathies). These neuromuscular diseases result from genetic mutations of a structural protein called dystrophin. The absence of functional dystrophin leads to the most common and severe form of muscular dystrophy, Duchenne muscular dystrophy (DMD). Typically, within one muscle bundle there are so-called fast and slow muscle fibers that shorten and lengthen at different speeds during muscle contraction. Using the multiscale muscle platform Mexie we evaluated how the lack of dystrophin affects the connective tissue deformation between these two types of muscle fibers. By adjusting the elasticity of extracellular matrix layer, we estimated the magnitude of the shear strain under unloaded and lightly loaded fiber contractions caused by differences in shortening velocities between fast and slow fibers. The simulations showed that without dystrophin large shear strains are generated causing local micro injury and inflammation leading to further muscle degeneration. The multiscale muscle modeling approach presented here could help accelerate understanding of DMD and lead to faster development of new drugs and treatments of patients.

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