Biological studies of organoselenium trans-palladium(II) complexes

dc.contributor.authorKesić, Ana
dc.contributor.authorRakovic, Ivana
dc.contributor.authorRadojevic, Ivana
dc.contributor.authorBogojeski, Jovana
dc.date.accessioned2021-12-14T11:59:20Z
dc.date.available2021-12-14T11:59:20Z
dc.date.issued2021
dc.description.abstractIn this work, two complexes of trans-palladium(II) with organoselenium compounds as their ligands were investigated., PdSe1, [Pd(L1)2Cl2], (L1 = 5- (phenylselanylmethyl) -dihydrofuran-2 (3H) -one)) and PdSe3, [Pd(L3)2Cl2], (L3 =2,2-dimethyl-3-(phenylselanylmethyl)-tetrahydro-2H-pyran). Their antimicrobial and antioxidant activity as well as the effect of the formed biofilm of selected bacteria were studied. Antimicrobial activity was tested by determining the minimum inhibitory concentrations (MIC) and minimum microbicidal concentration (MMC) using the resazurin microdilution plate method The effect of complexes and ligands on formed biofilm of S. aureus ATCC 25923, S. aureus, and P. aeruginosa was determined. The in vitro antioxidant activity of the complex was determined based on the neutralizing capacity of DPPH radicals expressed as EK50. The investigated complexes showed significantly higher antimicrobial activity than the corresponding ligands. The most significant activity was shown on Pseudomonas aeruginosa. Complexes showed a lower effect on tested bacterias formed biofilm than the tested ligands. Complex Pd-Se1 showed a better effect on the tested biofilm of S. aureus, while complex Pd-Se3 showed a significant effect on the tested biofilm of P. aeruginosa. The antioxidant activity of all n organoselenium trans-palladium(II) complexes is significant, with the PdSe1 complex being more active. These complexes have the potential to be further investigated as metallodrugs.en_US
dc.description.sponsorshipThe authors are grateful to the Ministry of Education, Science and Technological Development of the Republic of Serbia (Agreement No 451 03 9 2021 14 200378 451 03 68 2021 14 200122 and Agreement No 451 03 68 2021 14 200378 for financial supporten_US
dc.identifier.doi10.3390/ECMC2021-11448en_US
dc.identifier.urihttps://scidar.kg.ac.rs/handle/123456789/13801
dc.publisherSCIforumen_US
dc.rightsopenAccess
dc.rights.licenseBY-NC-ND
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.source7th edition of our series of International Electronic Conferences on Medicinal Chemistryen_US
dc.subjectAntimicrobial activityen_US
dc.subjectSeleniumen_US
dc.subjectPalladiumen_US
dc.subjectAntioxidant activityen_US
dc.subjectBiofilmen_US
dc.titleBiological studies of organoselenium trans-palladium(II) complexesen_US
dc.typeconferenceObjecten_US

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