Synthesis, cytotoxic activity, and thermal studies of novel N-[(1,3-diphenylpyrazol-4-yl)methyl] α-amino acids
Date
2010
Authors
Joksović, Milan
Bogdanovic, Gordana
Kojić, Vesna
Mészáros Szécsényi, Katalin
Leovac V.
Jakimov, Dimitar
Trifunović, Snežana
Marković, Violeta
Joksović, Ljubinka
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
(Chemical Equation Presented) New N-[(1,3-diphenylpyrazol-4-yl)methyl]a- amino acids (1a-i) have been synthesized and tested in vitro for their antiproliferative activity against human myelogenous leukemia K562, colon adenocarcinoma HT-29, cervix carcinoma HeLa, and normal fetal lung fibroblasts, MRC-5. Compounds derived from both phenylalanine enantiomer precursors appeared to be the most active against myelogenous leukemia K562 cell lines with a high cytotoxic potential. © 2010 HeteroCorporation.